[HTML][HTML] Peripheral blood stem cell mobilization: the CXCR2 ligand GROβ rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties

LM Pelus, S Fukuda - Experimental hematology, 2006 - Elsevier
Chemokines direct the movement of leukocytes, including hematopoietic stem and
progenitor cells, and can mobilize hematopoietic cells from marrow to peripheral blood
where they can be used for transplantation. In this review, we will discuss the stem cell
mobilizing activities and mechanisms of action of GROβ, a CXC chemokine ligand for the
CXCR2 receptor. GROβ rapidly mobilizes short-and long-term repopulating cells in mice
and/or monkeys and synergistically enhances mobilization responses when combined with …