Reprogramming metastatic tumour cells with embryonic microenvironments

MJC Hendrix, EA Seftor, REB Seftor… - Nature Reviews …, 2007 - nature.com
MJC Hendrix, EA Seftor, REB Seftor, J Kasemeier-Kulesa, PM Kulesa, LM Postovit
Nature Reviews Cancer, 2007nature.com
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing
to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human
stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype
of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic
signalling pathways, which may help to identify new targets for therapeutic intervention. This
Review will summarize the embryonic models used to reverse the metastatic melanoma …
Abstract
Aggressive tumour cells share many characteristics with embryonic progenitors, contributing to the conundrum of tumour cell plasticity. Recent studies using embryonic models of human stem cells, the zebrafish and the chick have shown the reversion of the metastatic phenotype of aggressive melanoma cells, and revealed the convergence of embryonic and tumorigenic signalling pathways, which may help to identify new targets for therapeutic intervention. This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration
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