RNA splicing during terminal erythropoiesis

JG Conboy - Current opinion in hematology, 2017 - journals.lww.com
JG Conboy
Current opinion in hematology, 2017journals.lww.com
Erythroid progenitors execute an elaborate alternative splicing program that modulates gene
expression posttranscriptionally, ultimately regulating the structure and function of the
proteome in a differentiation stage-specific manner during terminal erythropoiesis. This
program helps drive differentiation and ensure synthesis of the proper protein isoforms
required to produce mechanically stable red cells. Mutation or deficiency of key splicing
regulatory proteins disrupts the splicing program to cause disease.
Summary
Erythroid progenitors execute an elaborate alternative splicing program that modulates gene expression posttranscriptionally, ultimately regulating the structure and function of the proteome in a differentiation stage-specific manner during terminal erythropoiesis. This program helps drive differentiation and ensure synthesis of the proper protein isoforms required to produce mechanically stable red cells. Mutation or deficiency of key splicing regulatory proteins disrupts the splicing program to cause disease.
Lippincott Williams & Wilkins