[PDF][PDF] Leveraging rules of nonsense-mediated mRNA decay for genome engineering and personalized medicine

MW Popp, LE Maquat - Cell, 2016 - cell.com
MW Popp, LE Maquat
Cell, 2016cell.com
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and
regulatory process that plays direct roles in human health and disease. In this Minireview,
we discuss how understanding the molecular events that trigger NMD can facilitate strategic
targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and
treatments.
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA quality control and regulatory process that plays direct roles in human health and disease. In this Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strategic targeting of genes via CRISPR/Cas9 technologies and also inform disease diagnostics and treatments.
cell.com