Self-administration of heroin, acetylmethadol, morphine, and methadone in rhesus monkeys

SE Harrigan, DA Downs - Life sciences, 1978 - Elsevier
SE Harrigan, DA Downs
Life sciences, 1978Elsevier
Abstract Heroin, α-l-acetylmethadol (LAAM), morphine, and methadone each maintained
self-administration in rhesus monkeys. The order of relative potency was heroin≥ LAAM>
morphine≥ methadone. Total daily drug intake increased as dose per injection increased;
maximum daily intake was inversely related to relative potency. At high doses, self-injection
of methadone and LAAM caused stupor and/or respiratory failure in some monkeys. These
toxic effects were partly or completely reversible by naloxone.
Abstract
Abstract Heroin, α-l-acetylmethadol (LAAM), morphine, and methadone each maintained self-administration in rhesus monkeys. The order of relative potency was heroin≥ LAAM> morphine≥ methadone. Total daily drug intake increased as dose per injection increased; maximum daily intake was inversely related to relative potency. At high doses, self-injection of methadone and LAAM caused stupor and/or respiratory failure in some monkeys. These toxic effects were partly or completely reversible by naloxone.
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