[HTML][HTML] Immunoregulatory CD4-CD8- T cells as a potential therapeutic tool for transplantation, autoimmunity, and cancer

EE Hillhouse, JS Delisle, S Lesage - Frontiers in immunology, 2013 - frontiersin.org
EE Hillhouse, JS Delisle, S Lesage
Frontiers in immunology, 2013frontiersin.org
A central objective in organ transplantation and the treatment or prevention of autoimmune
disease is the achievement of antigen-specific immune tolerance. An additional challenge in
bone marrow transplantation for the treatment of hematological malignancies is the
prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity.
Interestingly, CD4-CD8-(double negative, DN) T cells, which exhibit a unique antigen-
specific immunoregulatory potential, appear to exhibit all of the properties to respond to …
A central objective in organ transplantation and the treatment or prevention of autoimmune disease is the achievement of antigen-specific immune tolerance. An additional challenge in bone marrow transplantation for the treatment of hematological malignancies is the prevention of graft-vs-host disease (GVHD) while maintaining graft-vs-tumor activity. Interestingly, CD4-CD8- (double negative, DN) T cells, which exhibit a unique antigen-specific immunoregulatory potential, appear to exhibit all of the properties to respond to these challenges. Herein, we review the therapeutic potential of immunoregulatory DN T cells in various immunopathological settings, including graft tolerance, GVHD, cancer, and autoimmunity.
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