Differential modulation of B7‐1 and B7‐2 isoform expression on human monocytes by cytokines which influence the development of T helper cell phenotype
WD Creery, F Diaz‐Mitoma, L Filion… - European journal of …, 1996 - Wiley Online Library
WD Creery, F Diaz‐Mitoma, L Filion, A Kumar
European journal of immunology, 1996•Wiley Online LibraryThe relative expression of B7 isoforms on APC may also be critical in determining the nature
and extent of the immune response [16-21]. Immunoregulatory cytokines may influence the
development of the Thl versus Th2 immune responses by altering the levels of B7 isoform
expression on APC. In particular, IL-10 and IL-12 have been suggested to elicit their
biological effects via B7 and CD28 molecules respectively [22, 231. The present studies
were conducted to evaluate the effect of immunoregulatory cytokines on B7 isoform …
and extent of the immune response [16-21]. Immunoregulatory cytokines may influence the
development of the Thl versus Th2 immune responses by altering the levels of B7 isoform
expression on APC. In particular, IL-10 and IL-12 have been suggested to elicit their
biological effects via B7 and CD28 molecules respectively [22, 231. The present studies
were conducted to evaluate the effect of immunoregulatory cytokines on B7 isoform …
The relative expression of B7 isoforms on APC may also be critical in determining the nature and extent of the immune response [16-21]. Immunoregulatory cytokines may influence the development of the Thl versus Th2 immune responses by altering the levels of B7 isoform expression on APC. In particular, IL-10 and IL-12 have been suggested to elicit their biological effects via B7 and CD28 molecules respectively [22, 231. The present studies were conducted to evaluate the effect of immunoregulatory cytokines on B7 isoform expression on resting and activated monocytes and B cells.
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