[HTML][HTML] Recent advances in CD8+ regulatory T cell research

Y Yu, X Ma, R Gong, J Zhu, L Wei… - Oncology …, 2018 - spandidos-publications.com
Y Yu, X Ma, R Gong, J Zhu, L Wei, J Yao
Oncology letters, 2018spandidos-publications.com
Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but
also serve important regulatory roles in the body's immune response. In particular, CD8+
regulatory T cells (CD8+ Tregs), which possess important immunosuppressive functions, are
able to effectively block the overreacting immune response and maintain the body's immune
homeostasis. In recent years, studies have identified a small set of special CD8+ Tregs that
can recognize major histocompatibility complex class Ib molecules, more specifically Qa‑1 in …
Abstract
Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but also serve important regulatory roles in the body's immune response. In particular, CD8+ regulatory T cells (CD8+ Tregs), which possess important immunosuppressive functions, are able to effectively block the overreacting immune response and maintain the body's immune homeostasis. In recent years, studies have identified a small set of special CD8+ Tregs that can recognize major histocompatibility complex class Ib molecules, more specifically Qa‑1 in mice and HLA‑E in humans, and target the self‑reactive CD4+ T ce lls. These findings have generated broad implications in the scientific community and attracted general interest to CD8+ Tregs. The present study reviews the recent research progress on CD8+ Tregs, including their origin, functional classification, molecular markers and underlying mechanisms of action.
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