[HTML][HTML] Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3

S Karvinen, S Pasonen-Seppänen… - Journal of Biological …, 2003 - ASBMB
Keratinocyte growth factor (KGF) activates keratinocyte migration and stimulates wound
healing. Hyaluronan, an extracellular matrix glycosaminoglycan that accumulates in
wounded epidermis, is known to promote cell migration, suggesting that increased synthesis
of hyaluronan might be associated with the KGF response in keratinocytes. Treatment of
monolayer cultures of rat epidermal keratinocytes led to an elongated and lifted cell shape,
increased filopodial protrusions, enhanced cell migration, accumulation of intermediate size …