Activation and proliferation of PD-1+ kidney double-negative T cells is dependent on nonclassical MHC proteins and IL-2
M Sadasivam, S Noel, SA Lee, J Gong… - Journal of the …, 2019 - journals.lww.com
Background CD4− CD8− double-negative (DN) αβ T cells with innate-like properties
represent a significant component of T cells in human and mouse kidneys. They
spontaneously proliferate in the steady state and protect against ischemic AKI. However, the
mechanisms regulating DN T cell homeostasis and responses to external danger signals
from “sterile” inflammation remain poorly understood. Methods We used knockout mice,
functional assays, and an established ischemic AKI model to investigate the role of various …
represent a significant component of T cells in human and mouse kidneys. They
spontaneously proliferate in the steady state and protect against ischemic AKI. However, the
mechanisms regulating DN T cell homeostasis and responses to external danger signals
from “sterile” inflammation remain poorly understood. Methods We used knockout mice,
functional assays, and an established ischemic AKI model to investigate the role of various …