[HTML][HTML] Inducible transgenes under the control of the hCD68 promoter identifies mouse macrophages with a distribution that differs from the F4/80-and CSF-1R …

MM Pillai, B Hayes, B Torok-Storb - Experimental hematology, 2009 - Elsevier
OBJECTIVE: Macrophages are critical components of diverse microenvironments (ME) in
adulthood, as well as during embryogenesis. Their role in development precludes the use of
gene-targeting and knockout approaches for studying their function. Hence, we proposed to
create a macrophage-specific inducible transgenic mouse where genes can be turned on or
off at will. MATERIALS AND METHODS: A transgenic mouse in which the reverse
tetracycline activator (rtTA-M2) is expressed under the hCD68 promoter for macrophage …