Species differences of 11beta-hydroxysteroid dehydrogenase type 2 function in human and rat term placenta determined via LC-MS/MS

K Heussner, M Ruebner, H Huebner, W Rascher… - Placenta, 2016 - Elsevier
Introduction Glucocorticoid-induced fetal programming has been associated with negative
metabolic and cardiovascular sequelae in the adult. The placental enzyme 11beta-
hydroxysteroid dehydrogenase type 2 (11β-HSD2) shields the fetus from maternal
glucocorticoid excess by catalyzing the conversion of these hormones into biologically
inactive derivatives. In vivo experiments addressing placental barrier function are mostly
conducted in rodents. Therefore we set out to characterize species-specific differences of rat …