Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos–overexpressing bone lesions
TG Kashima, T Nishiyama, K Shimazu, M Shimazaki… - Human pathology, 2009 - Elsevier
Fibrous dysplasia is a benign bone disease caused by a mutation in the gene for the
stimulatory guanine nucleotide-binding protein Gsα, leading to high cyclic adenosine
monophosphate levels. Histologically, fibrous dysplasia is characterized by the production of
fibrous tissue accompanied by the deposition of ectopic type I collagen and other bone-
associated extracellular matrix proteins, as well as by irregular woven intramembranous
bone onto which type I collagen-containing Sharpey fibers are often attached. Fibrous …
stimulatory guanine nucleotide-binding protein Gsα, leading to high cyclic adenosine
monophosphate levels. Histologically, fibrous dysplasia is characterized by the production of
fibrous tissue accompanied by the deposition of ectopic type I collagen and other bone-
associated extracellular matrix proteins, as well as by irregular woven intramembranous
bone onto which type I collagen-containing Sharpey fibers are often attached. Fibrous …