Context Existing therapies for major depression have a lag of onset of action of several
weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have
rapid onset of antidepressant effects within a few days and that are sustained would have an
enormous impact on patient care. Converging lines of evidence suggest the role of the
glutamatergic system in the pathophysiology and treatment of mood disorders. Objective To
determine whether a rapid antidepressant effect can be achieved with an antagonist at theN …