The DEK protein—an abundant and ubiquitous constituent of mammalian chromatin
T Waldmann, I Scholten, F Kappes, HG Hu, R Knippers - Gene, 2004 - Elsevier
T Waldmann, I Scholten, F Kappes, HG Hu, R Knippers
Gene, 2004•ElsevierThe protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms
(not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating
mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a
sequence motif that DEK shares with a number of other chromatin proteins. DEK has no
apparent affinity to specific DNA sequences, but preferentially binds to superhelical and
cruciform DNA, and induces positive supercoils into closed circular DNA. The available …
(not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating
mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a
sequence motif that DEK shares with a number of other chromatin proteins. DEK has no
apparent affinity to specific DNA sequences, but preferentially binds to superhelical and
cruciform DNA, and induces positive supercoils into closed circular DNA. The available …
The protein DEK is an abundant and ubiquitous chromatin protein in multicellular organisms (not in yeast). It is expressed in more than a million copies/nucleus of rapidly proliferating mammalian cells. DEK has two DNA binding modules of which one includes a SAP box, a sequence motif that DEK shares with a number of other chromatin proteins. DEK has no apparent affinity to specific DNA sequences, but preferentially binds to superhelical and cruciform DNA, and induces positive supercoils into closed circular DNA. The available evidence strongly suggests that DEK could function as an architectural protein in chromatin comparable to the better known classic architectural chromatin proteins, the high-mobility group or HMG proteins.
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