Activity-dependent brain-derived neurotrophic factor release is required for the rapid antidepressant actions of scopolamine
S Ghosal, E Bang, W Yue, BD Hare, AE Lepack… - Biological …, 2018 - Elsevier
Background Brain-derived neurotrophic factor (BDNF) plays a key role in the
pathophysiology and treatment of depression. Recent clinical studies demonstrate that
scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid
antidepressant effects in patients with depression. Rodent studies demonstrate that
scopolamine increases glutamate transmission and synaptogenesis in the medial prefrontal
cortex (mPFC). Here we tested the hypothesis that activity-dependent BDNF release within …
pathophysiology and treatment of depression. Recent clinical studies demonstrate that
scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid
antidepressant effects in patients with depression. Rodent studies demonstrate that
scopolamine increases glutamate transmission and synaptogenesis in the medial prefrontal
cortex (mPFC). Here we tested the hypothesis that activity-dependent BDNF release within …