[HTML][HTML] Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic …

M Osada, O Inoue, G Ding, T Shirai, H Ichise… - Journal of Biological …, 2012 - ASBMB
The platelet activation receptor CLEC-2 plays crucial roles in thrombosis/hemostasis, tumor
metastasis, and lymphangiogenesis, although its role in thrombosis/hemostasis remains
controversial. An endogenous ligand for CLEC-2, podoplanin, is expressed in lymphatic
endothelial cells (LECs). We and others have reported that CLEC-2-deficiency is lethal at
mouse embryonic/neonatal stages associated with blood-filled lymphatics, indicating that
CLEC-2 is essential for blood/lymphatic vessel separation. However, its mechanism, and …