[HTML][HTML] High activity suppression of myeloid progenitor proliferation by chimeric mutants of interleukin 8 and platelet factor 4 (∗)
TJ Daly, GJ LaRosa, S Dolich, TE Maione… - Journal of Biological …, 1995 - ASBMB
The proliferation of human myeloid progenitor cells is negatively regulated in the presence
of certain members of the chemokine family of molecules. This includes interleukin 8 (IL-8)
and platelet factor 4 (PF4), which in combination are able to synergize, resulting in cell
suppression at very low concentrations of these molecules. A series of PF4 and IL-8 mutant
proteins were analyzed in an in vitro colony formation assay for myeloid progenitor cells to
assess domains of these proteins that are required for activity. Mutation of either of the two …
of certain members of the chemokine family of molecules. This includes interleukin 8 (IL-8)
and platelet factor 4 (PF4), which in combination are able to synergize, resulting in cell
suppression at very low concentrations of these molecules. A series of PF4 and IL-8 mutant
proteins were analyzed in an in vitro colony formation assay for myeloid progenitor cells to
assess domains of these proteins that are required for activity. Mutation of either of the two …