[HTML][HTML] Inositol 1, 4, 5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities
S Windhorst, R Fliegert, C Blechner, K Möllmann… - Journal of biological …, 2010 - ASBMB
Cellular migration is an essential prerequisite for metastatic dissemination of cancer cells.
This study demonstrates that the neuron/testis-specific F-actin-targeted inositol 1, 4, 5-
trisphosphate 3-kinase-A (ITPKA) is ectopically expressed in different human tumor cell lines
and during tumor progression in the metastatic tumor model Balb-neuT. High expression of
ITPKA increases invasive migration in vitro and metastasis in a xenograft SCID mouse
model. Mechanistic studies show that ITPKA promotes migration of tumor cells by two …
This study demonstrates that the neuron/testis-specific F-actin-targeted inositol 1, 4, 5-
trisphosphate 3-kinase-A (ITPKA) is ectopically expressed in different human tumor cell lines
and during tumor progression in the metastatic tumor model Balb-neuT. High expression of
ITPKA increases invasive migration in vitro and metastasis in a xenograft SCID mouse
model. Mechanistic studies show that ITPKA promotes migration of tumor cells by two …