Necroptosis and its role in inflammation

M Pasparakis, P Vandenabeele - Nature, 2015 - nature.com
Nature, 2015nature.com
Regulated cell death has essential functions in development and in adult tissue
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires
the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like
receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has
important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and
apoptosis. Mouse-model studies have revealed important functions for necroptosis in …
Abstract
Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires the proteins RIPK3 and MLKL and is induced by death receptors, interferons, toll-like receptors, intracellular RNA and DNA sensors, and probably other mediators. RIPK1 has important kinase-dependent and scaffolding functions that inhibit or trigger necroptosis and apoptosis. Mouse-model studies have revealed important functions for necroptosis in inflammation and suggested that it could be implicated in the pathogenesis of many human inflammatory diseases. We discuss the mechanisms regulating necroptosis and its potential role in inflammation and disease.
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