Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1–mediated ischemia-reperfusion injury after lung transplantation
T Kanou, A Ohsumi, H Kim, M Chen, X Bai… - The Journal of Heart and …, 2018 - Elsevier
Background Increasing evidence indicates that regulated necrosis plays a critical role during
cell death caused by ischemia-reperfusion (IR) injury. Necroptosis is one form of regulated
necrosis. Necrostatin-1 (Nec-1), an inhibitor of receptor-interacting protein kinase 1 (RIPK1),
is known to reduce necroptosis. We investigated the effect of Nec-1 treatment on IR-induced
lung injury in a rat lung transplant model. Methods Lewis rats were divided into 4 groups (n=
6 each):(1) Control (no treatment),(2) Donor treatment (D),(3) Recipient treatment (R), and …
cell death caused by ischemia-reperfusion (IR) injury. Necroptosis is one form of regulated
necrosis. Necrostatin-1 (Nec-1), an inhibitor of receptor-interacting protein kinase 1 (RIPK1),
is known to reduce necroptosis. We investigated the effect of Nec-1 treatment on IR-induced
lung injury in a rat lung transplant model. Methods Lewis rats were divided into 4 groups (n=
6 each):(1) Control (no treatment),(2) Donor treatment (D),(3) Recipient treatment (R), and …