Autophagy has been shown to be important for normal homeostasis and adaptation to stress
in the kidney. Yet, the molecular mechanisms regulating renal epithelial autophagy are not
fully understood. Here, we explored the role of the stress-responsive transcription factor
forkhead box O3 (FoxO3) in mediating injury-induced proximal tubular autophagy in mice
with unilateral ureteral obstruction (UUO). We show that following UUO, FoxO3 is activated
and displays nuclear expression in the hypoxic proximal tubules exhibiting high levels of …