[HTML][HTML] Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system: evidence for a role in …

RJ Denver, L Ouellet, D Furling, A Kobayashi… - Journal of Biological …, 1999 - ASBMB
Thyroid hormone (3, 5, 3′-triiodothyronine; T 3) is essential for normal development of the
vertebrate brain, influencing diverse processes such as neuronal migration, myelin
formation, axonal maturation, and dendritic outgrowth. We have identified basic transcription
element-binding protein (BTEB), a small GC box-binding protein, as a T 3-regulated gene in
developing rat brain. BTEB mRNA levels in cerebral cortex exhibit developmental regulation
and thyroid hormone dependence. T 3 regulation of BTEB mRNA is neural cell-specific …