ABIN1 dysfunction as a genetic basis for lupus nephritis
DJ Caster, EA Korte, SK Nanda… - Journal of the …, 2013 - journals.lww.com
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic
lupus erythematosus are largely unknown, although animal studies indicate that nuclear
factor (NF)-κB is involved. We reported previously that a knockin mouse expressing an
inactive form of ABIN1 (ABIN1 [D485N]) develops lupus-like autoimmune disease and
demonstrates enhanced activation of NF-κB and mitogen-activated protein kinases in
immune cells after toll-like receptor stimulation. In the current study, we show that ABIN1 …
lupus erythematosus are largely unknown, although animal studies indicate that nuclear
factor (NF)-κB is involved. We reported previously that a knockin mouse expressing an
inactive form of ABIN1 (ABIN1 [D485N]) develops lupus-like autoimmune disease and
demonstrates enhanced activation of NF-κB and mitogen-activated protein kinases in
immune cells after toll-like receptor stimulation. In the current study, we show that ABIN1 …