Lupus nephritis and end-stage kidney disease
N Maroz, MS Segal - The American journal of the medical sciences, 2013 - Elsevier
Systemic lupus erythematosus (SLE) is a multisystem disease affecting many organs.
Varying degrees of renal involvement are seen in up to 60% of adults with SLE, and severe
lupus nephritis (LN)(World Health Organization class III and above) progresses to end-stage
kidney disease (ESKD) within 15 years of diagnosis in 10% to 30% of patients. In fact, renal
injury is the most important predictor of mortality in patients with SLE. Identifying patients at
risk of progression to ESKD and providing them with aggressive and appropriate …
Varying degrees of renal involvement are seen in up to 60% of adults with SLE, and severe
lupus nephritis (LN)(World Health Organization class III and above) progresses to end-stage
kidney disease (ESKD) within 15 years of diagnosis in 10% to 30% of patients. In fact, renal
injury is the most important predictor of mortality in patients with SLE. Identifying patients at
risk of progression to ESKD and providing them with aggressive and appropriate …