Antibodies to neurofascin exacerbate adoptive transfer experimental autoimmune neuritis

W Yan, T Nguyen, N Yuki, Q Ji, C Yiannikas… - Journal of …, 2014 - Elsevier
Guillain–Barré syndrome and chronic inflammatory demyelinating polyneuropathy are
autoimmune disorders of the peripheral nervous system in which autoantibodies are
implicated in the disease pathogenesis. Recent work has focused on the nodal regions of
the myelinated axon as potential autoantibody targets. Here we screened patient sera for
autoantibodies to neurofascin and assessed the pathophysiological relevance of anti-
neurofascin antibodies in vivo. Levels of anti-neurofascin antibodies were higher in sera …