Aiding and abetting roles of NOX oxidases in cellular transformation

K Block, Y Gorin - Nature Reviews Cancer, 2012 - nature.com
K Block, Y Gorin
Nature Reviews Cancer, 2012nature.com
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive
signalling pathways that are involved in cancer development and progression. They act at
specific cellular membranes and microdomains through the activation of oncogenes and the
inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and
redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological …
Abstract
NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.
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