Inositol 1, 4, 5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells
Y Maréchal, S Quéant, S Polizzi, V Pouillon… - Immunobiology, 2011 - Elsevier
Inositol 1, 4, 5-trisphosphate 3-kinase B (or Itpkb) and inositol 1, 3, 4, 5-tetrakisphosphate
(Ins (1, 3, 4, 5) P4), its reaction product, play an important role in the control of B lymphocyte
fate and function in vivo. In order to investigate the fine mechanisms of Itpkb and Ins (1, 3, 4,
5) P4 action in B cells, we crossed Itpkb−/− mice with transgenic mice expressing a 3-83μδ B
cell receptor (BCR) specific for membrane-bound MHC-I H2-Kb and H2-Kk molecules. On a
non-deleting H2-Kd genetic background, we show that Itpkb is important for the control of …
(Ins (1, 3, 4, 5) P4), its reaction product, play an important role in the control of B lymphocyte
fate and function in vivo. In order to investigate the fine mechanisms of Itpkb and Ins (1, 3, 4,
5) P4 action in B cells, we crossed Itpkb−/− mice with transgenic mice expressing a 3-83μδ B
cell receptor (BCR) specific for membrane-bound MHC-I H2-Kb and H2-Kk molecules. On a
non-deleting H2-Kd genetic background, we show that Itpkb is important for the control of …