Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17

XY Cai, CP Gommoll Jr, L Justice, SK Narula, JS Fine - Immunology Letters, 1998 - Elsevier
Interleukin-17 (IL-17) has been previously reported to induce stromal cells to produce a
number of hematopoietic and proinflammatory cytokines, including granulocyte colony-
stimulating factor (G-CSF). Here, we have evaluated the mechanisms responsible for the
augmentation of G-CSF gene expression by IL-17, using the murine 3T3 fibroblast cell line.
Treatment of 3T3 cells, but not primary bone marrow-derived macrophages or murine
monocyte/macrophage cell lines, resulted in increased steady-state G-CSF mRNA levels …