Quantitative assessment of atherosclerotic lesions in mice
B Paigen, A Morrow, PA Holmes, D Mitchell… - Atherosclerosis, 1987 - Elsevier
The well-defined genetic systems of the mouse are proving useful in experimental studies of
atherosclerosis. Inbred mouse strains differ in atherosclerosis susceptibility, and several
variants of apolipoproteins have been identified and mapped. This report explores the
location and timing of lesion formation in the mouse in an effort to provide a basis for
quantitatively comparing groups of mice. After 14 weeks on an atherogenic diet containing
1.25% cholesterol, 15% fat, and 0.5% cholic acid, C57BL/6J female mice had aortic lesions …
atherosclerosis. Inbred mouse strains differ in atherosclerosis susceptibility, and several
variants of apolipoproteins have been identified and mapped. This report explores the
location and timing of lesion formation in the mouse in an effort to provide a basis for
quantitatively comparing groups of mice. After 14 weeks on an atherogenic diet containing
1.25% cholesterol, 15% fat, and 0.5% cholic acid, C57BL/6J female mice had aortic lesions …