[HTML][HTML] Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice
T Ishida, SY Choi, RK Kundu, J Spin… - Journal of Biological …, 2004 - ASBMB
Endothelial lipase (EL) expression correlates inversely with circulating high density
lipoprotein (HDL) cholesterol levels in genetic mouse models, and human genetic variation
in this locus has been linked to differences in HDL cholesterol levels. These data suggest a
role for EL in the development of atherosclerotic vascular disease. To investigate this
possibility, LIPG-null alleles were bred onto the apoE knockout background, and the
homozygous double knockout animals were characterized. Both apoE knockout and double …
lipoprotein (HDL) cholesterol levels in genetic mouse models, and human genetic variation
in this locus has been linked to differences in HDL cholesterol levels. These data suggest a
role for EL in the development of atherosclerotic vascular disease. To investigate this
possibility, LIPG-null alleles were bred onto the apoE knockout background, and the
homozygous double knockout animals were characterized. Both apoE knockout and double …