The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation
The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that
participate in the removal of cholesterol from lipid-laden macrophages, a crucial anti-
atherogenic mechanism. Statins are currently the most efficacious therapy for the treatment
of hypercholesterolemia and cardiovascular disease. We and others have shown that statins
decrease ABCA1 and ABCG1 expression as well as cholesterol efflux from human
macrophages. However, other studies have reported that statins produce no change, or …
participate in the removal of cholesterol from lipid-laden macrophages, a crucial anti-
atherogenic mechanism. Statins are currently the most efficacious therapy for the treatment
of hypercholesterolemia and cardiovascular disease. We and others have shown that statins
decrease ABCA1 and ABCG1 expression as well as cholesterol efflux from human
macrophages. However, other studies have reported that statins produce no change, or …