Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy

HM Ni, BL Woolbright, J Williams, B Copple, W Cui… - Journal of …, 2014 - Elsevier
Background & Aims Autophagy is an intracellular lysosomal degradation process that plays
an important role in regulating normal physiological functions of the liver. The purpose of the
present study was to investigate the mechanism (s) by which the loss of hepatic autophagy
leads to liver inflammation, fibrosis and tumorigenesis. Methods Hepatocyte-specific Atg5
knockout mice were generated by crossing Atg5 Flox/Flox mice with albumin Cre mice.
These mice were also crossed with Nrf2 knockout mice to generate Atg5 Flox/Flox, Albumin …