[HTML][HTML] Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor γ ligands and agonists

SS Davies, AV Pontsler, GK Marathe… - Journal of Biological …, 2001 - ASBMB
Synthetic high affinity peroxisome proliferator-activated receptor (PPAR) agonists are
known, but biologic ligands are of low affinity. Oxidized low density lipoprotein (oxLDL) is
inflammatory and signals through PPARs. We showed, by phospholipase A 1 digestion, that
PPARγ agonists in oxLDL arise from the small pool of alkyl phosphatidylcholines in LDL. We
identified an abundant oxidatively fragmented alkyl phospholipid in oxLDL, hexadecyl
azelaoyl phosphatidylcholine (azPC), as a high affinity ligand and agonist for PPARγ.[3 H] …