Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years

MA Espeland, SA Shumaker, I Leng… - JAMA internal …, 2013 - jamanetwork.com
Importance Postmenopausal hormone therapy with conjugated equine estrogens (CEEs)
may adversely affect older women's cognitive function. It is not known whether this extends
to younger women. Objective To test whether prescribing CEE-based hormone therapy to
postmenopausal women aged 50 to 55 years has longer-term effects on cognitive function.
Design Trained, masked staff assessed participants with an annual telephone-administered
cognitive battery that included measures of global and domain-specific cognitive functions …