[HTML][HTML] Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas
LB Beder, M Gunduz, M Ouchida, K Fukushima… - Laboratory …, 2003 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is a frequent malignancy with a poor
survival rate. Identifying the tumor suppressor gene (TSG) loci by genomic studies is an
important step to uncover the molecular mechanisms involved in HNSCC pathogenesis. We
therefore performed comprehensive analyses on loss of heterozygosity (LOH) using a
genome-wide panel of 191 microsatellite markers in 22 HNSCC samples. We found 53
markers with significantly high LOH (> 30%) on 21 chromosomal arms; the highest values of …
survival rate. Identifying the tumor suppressor gene (TSG) loci by genomic studies is an
important step to uncover the molecular mechanisms involved in HNSCC pathogenesis. We
therefore performed comprehensive analyses on loss of heterozygosity (LOH) using a
genome-wide panel of 191 microsatellite markers in 22 HNSCC samples. We found 53
markers with significantly high LOH (> 30%) on 21 chromosomal arms; the highest values of …