[HTML][HTML] Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes
WF Loomis, MM Behrens, ME Williams… - Journal of biological …, 2010 - ASBMB
Acyl-CoA-binding protein (ACBP) functions both intracellularly as part of fatty acid
metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine
peptides. Two of these peptides, ODN and TTN, bind to the GABA A receptor and modulate
its sensitivity to γ-aminobutyric acid (GABA). We have found that depolarization of mouse
primary astrocytes induces the rapid release and processing of ACBP to the active peptides.
We previously showed that ODN can trigger the rapid sporulation of the social amoeba …
metabolism and extracellularly as diazepam binding inhibitor, the precursor of endozepine
peptides. Two of these peptides, ODN and TTN, bind to the GABA A receptor and modulate
its sensitivity to γ-aminobutyric acid (GABA). We have found that depolarization of mouse
primary astrocytes induces the rapid release and processing of ACBP to the active peptides.
We previously showed that ODN can trigger the rapid sporulation of the social amoeba …