Expanded and armed natural killer cells for cancer treatment

N Shimasaki, E Coustan-Smith, T Kamiya, D Campana - Cytotherapy, 2016 - Elsevier
The capacity of natural killer (NK) cells to recognize and kill transformed cells suggests that
their infusion could be used to treat cancer. It is difficult to obtain large numbers of NK cells
ex vivo by exposure to cytokines alone but the addition of stimulatory cells to the cultures
can induce NK cell proliferation and long-term expansion. Some of these methods have
been validated for clinical-grade application and support clinical trials testing feasibility and
safety of NK cell administration. Early data indicate that ex vivo expansion of NK cells from …