[HTML][HTML] Interferon-γ induction of the human leukocyte antigen-E gene is mediated through binding of a complex containing STAT1α to a distinct interferon-γ …
KS Gustafson, GD Ginder - Journal of Biological Chemistry, 1996 - ASBMB
Expression of the human major histocompatibility complex (MHC) class I genes has been
shown previously to increase at the transcriptional level following exposure to interferon-γ
(IFN-γ). In this report we have examined the molecular mechanisms involved in the IFN-γ-
induced transcription of the human MHC class I gene, HLA-E. Functional analysis of CAT
reporter gene constructs under the control of the HLA-E promoter transfected into U937 cells
revealed the presence of a distinct IFN-γ-responsive element, termed the interferon …
shown previously to increase at the transcriptional level following exposure to interferon-γ
(IFN-γ). In this report we have examined the molecular mechanisms involved in the IFN-γ-
induced transcription of the human MHC class I gene, HLA-E. Functional analysis of CAT
reporter gene constructs under the control of the HLA-E promoter transfected into U937 cells
revealed the presence of a distinct IFN-γ-responsive element, termed the interferon …