Does persistent HIV replication explain continued lymphoma incidence in the era of effective antiretroviral therapy?
J Totonchy, E Cesarman - Current opinion in virology, 2016 - Elsevier
Highlights•Control of HIV with cART fails to reduce the incidence of many lymphomas.•
Replication of HIV in lymph nodes may affect lymphoma risk during therapy.•Replication of
HIV in adipose tissue may create a lymphoma-promoting metabolic state.•HIV pathology in
reservoirs may inform mechanisms of cART-resistant lymphoma risk.Non-Hodgkin
lymphomas are highly increased in incidence in individuals infected with HIV, and this
continues to be the case in spite of highly effective combined antiretroviral therapy (cART) …
Replication of HIV in lymph nodes may affect lymphoma risk during therapy.•Replication of
HIV in adipose tissue may create a lymphoma-promoting metabolic state.•HIV pathology in
reservoirs may inform mechanisms of cART-resistant lymphoma risk.Non-Hodgkin
lymphomas are highly increased in incidence in individuals infected with HIV, and this
continues to be the case in spite of highly effective combined antiretroviral therapy (cART) …