[PDF][PDF] Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and lymphoproliferative disorders after …

V Icheva, S Kayser, D Wolff, S Tuve, C Kyzirakos… - J Clin Oncol, 2013 - Citeseer
V Icheva, S Kayser, D Wolff, S Tuve, C Kyzirakos, W Bethge, J Greil, MH Albert, W Schwinger…
J Clin Oncol, 2013Citeseer
Purpose Reactivation of Epstein-Barr virus (EBV) after allogeneic stem-cell transplantation
(SCT) can lead to severe life-threatening infections and trigger post-transplantation
lymphoproliferative disease (PTLD). Since EBV-specific T cells could prevent PTLD, cellular
immunotherapy has been a promising treatment option. However, generation of antigen-
specific T-cell populations has been difficult within a short time frame.
Purpose
Reactivation of Epstein-Barr virus (EBV) after allogeneic stem-cell transplantation (SCT) can lead to severe life-threatening infections and trigger post-transplantation lymphoproliferative disease (PTLD). Since EBV-specific T cells could prevent PTLD, cellular immunotherapy has been a promising treatment option. However, generation of antigen-specific T-cell populations has been difficult within a short time frame.
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