[PDF][PDF] Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function

BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein… - Cell stem cell, 2014 - cell.com
BLM Hogan, CE Barkauskas, HA Chapman, JA Epstein, R Jain, CCW Hsia, L Niklason…
Cell stem cell, 2014cell.com
Respiratory disease is the third leading cause of death in the industrialized world.
Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of
extensive investigations. Recent studies have provided new information about the
mechanisms driving lung development and differentiation. However, there is still much to
learn about the ability of the adult respiratory system to undergo repair and to replace cells
lost in response to injury and disease. This Review highlights the multiple stem/progenitor …
Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.
cell.com