[HTML][HTML] Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce …
SA Shell, C Hesse, SM Morris, C Milcarek - Journal of Biological Chemistry, 2005 - ASBMB
Lipopolysaccharide (LPS) activation of murine RAW 264.7 macrophages influences the
expression of multiple genes through transcriptional and post-transcriptional mechanisms.
We observed a 5-fold increase in CstF-64 expression following LPS treatment of RAW
macrophages. The increase in CstF-64 protein was specific in that several other factors
involved in 3′-end processing were not affected by LPS stimulation. Activation of RAW
macrophages with LPS caused an increase in proximal poly (A) site selection within a …
expression of multiple genes through transcriptional and post-transcriptional mechanisms.
We observed a 5-fold increase in CstF-64 expression following LPS treatment of RAW
macrophages. The increase in CstF-64 protein was specific in that several other factors
involved in 3′-end processing were not affected by LPS stimulation. Activation of RAW
macrophages with LPS caused an increase in proximal poly (A) site selection within a …