[HTML][HTML] Guiding postablative lymphocyte reconstitution as a route toward transplantation tolerance
G Piotti, J Ma, E Adams, S Cobbold… - American Journal of …, 2014 - Elsevier
Anti-lymphocyte-depleting antibodies have increasingly been utilized in the clinic as
induction therapy aiming to improve transplantation outcomes by reducing the need for long-
term immunosuppression. However, maintenance immunosuppression is still required as
lymphocyte reconstitution through homeostatic proliferation, partially driven by IL-7,
continues to replenish tolerance-refractory immune cells capable of rejection. In murine
models of MHC mismatched skin grafting, we investigated whether it is feasible to control the …
induction therapy aiming to improve transplantation outcomes by reducing the need for long-
term immunosuppression. However, maintenance immunosuppression is still required as
lymphocyte reconstitution through homeostatic proliferation, partially driven by IL-7,
continues to replenish tolerance-refractory immune cells capable of rejection. In murine
models of MHC mismatched skin grafting, we investigated whether it is feasible to control the …