[HTML][HTML] Resident CD4+ T cells accumulate in lymphoid organs after prolonged antigen exposure

M Ugur, O Schulz, MB Menon, A Krueger… - Nature …, 2014 - nature.com
Nature communications, 2014nature.com
Effector and memory CD4+ T cells acquire distinct migratory properties depending on the
type and location of the immune responses. Due to the highly dynamic nature of T cell
circulation, the comprehensive analysis of these migratory routes requires dedicated
experimental approaches. Here, we analyse the migration of effector/memory CD4+ T cells
by long-term in vivo cell tracking. We identify a resident population of antigen-experienced
CD4+ T cells that resides in lymph nodes and Peyer's patches without circulation or …
Abstract
Effector and memory CD4+ T cells acquire distinct migratory properties depending on the type and location of the immune responses. Due to the highly dynamic nature of T cell circulation, the comprehensive analysis of these migratory routes requires dedicated experimental approaches. Here, we analyse the migration of effector/memory CD4+ T cells by long-term in vivo cell tracking. We identify a resident population of antigen-experienced CD4+ T cells that resides in lymph nodes and Peyer’s patches without circulation or proliferation. Resident CD4+ T cells constitute up to 50% of all effector/memory cells, including, but not limited to, follicular helper T cells. Furthermore, these non-circulating T cells possess a distinct T cell receptor repertoire and accumulate in Peyer’s patches after continuous oral antigen exposure. Our results provide the first direct evidence for a resident population of effector/memory CD4+ T cells that is retained in lymphoid tissues.
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