[HTML][HTML] The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells

I Dumler, A Weis, OA Mayboroda, C Maasch… - Journal of Biological …, 1998 - ASBMB
The binding of urokinase plasminogen activator (uPA) to its specific receptor (uPAR)
facilitates migration of vascular smooth muscle cells (VSMC). However, the signaling
cascade utilized by the urokinase receptor is only incompletely understood. We investigated
intracellular uPA/uPAR signaling in human aortic VSMC from the cell membrane to the
nucleus. uPA binding to VSMC induced a rapid and pronounced increase in tyrosine
phosphorylation of several proteins with molecular masses of 53–60, 85–90, and 130–140 …