The relationship between cyclooxygenase-2 expression and colorectal cancer

KM Sheehan, K Sheahan, DP O'Donoghue… - Jama, 1999 - jamanetwork.com
ContextEpidemiological studies have implicated the inducible form of cyclooxygenase (COX-
2) in the pathogenesis of colorectal cancer; however, its role is not fully understood.
ObjectiveTo examine the relationship between the expression of COX-2 in human colorectal
cancer and patient survival. DesignPatients diagnosed as having colorectal cancer were
evaluated and followed up for up to 9.4 years (median follow-up, 2.7 years). Tumor sections
were stained for COX-2 using a rabbit polyclonal antibody raised against human COX-2 …