Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes
S Mendoza, H David, GM Gaylord, CW Miller - Cancer genetics and …, 2005 - Elsevier
Loss of heterozygosity at 10q26 was mapped using microsatellite markers in 20
osteosarcomas. A four-megabase region centered on marker D10S587 was affected by
allelic loss in 60 percent of osteosarcomas. The most frequently lost marker was D10S1723.
Around 15 known genes are found in this region. The gene immediately adjacent to
D10S1723 encodes BUB3, an element of the spindle assembly mitotic checkpoint. Loss of
BUB3 function could contribute to chromosomal instability. The fibroblast growth factor …
osteosarcomas. A four-megabase region centered on marker D10S587 was affected by
allelic loss in 60 percent of osteosarcomas. The most frequently lost marker was D10S1723.
Around 15 known genes are found in this region. The gene immediately adjacent to
D10S1723 encodes BUB3, an element of the spindle assembly mitotic checkpoint. Loss of
BUB3 function could contribute to chromosomal instability. The fibroblast growth factor …