Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models

R Skouta, SJ Dixon, J Wang, DE Dunn… - Journal of the …, 2014 - ACS Publications
R Skouta, SJ Dixon, J Wang, DE Dunn, M Orman, K Shimada, PA Rosenberg, DC Lo…
Journal of the American Chemical Society, 2014ACS Publications
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell
death. We found that Fer-1 inhibited cell death in cellular models of Huntington's disease
(HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid
peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal
membrane permeability. We developed a mechanistic model to explain the activity of Fer-1,
which guided the development of ferrostatins with improved properties. These studies …
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death. We found that Fer-1 inhibited cell death in cellular models of Huntington’s disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability. We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties. These studies suggest numerous therapeutic uses for ferrostatins, and that lipid peroxidation mediates diverse disease phenotypes.
ACS Publications