[HTML][HTML] Influence of donor microbiota on the severity of experimental graft-versus-host-disease
Biology of Blood and Marrow Transplantation, 2013•Elsevier
The link between microbial flora and the shaping of immune responses is being increasingly
appreciated, and recent data have uncovered a role for recipient microbiota in the severity of
graft-versus-host disease (GVHD). The impact of donor microbiota on T cell–mediated
alloresponses and GVHD is not known, however. Using multiple clinically relevant murine
models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T
cells from specific pathogen-free and germ-free donors, and found that donor microbiota …
appreciated, and recent data have uncovered a role for recipient microbiota in the severity of
graft-versus-host disease (GVHD). The impact of donor microbiota on T cell–mediated
alloresponses and GVHD is not known, however. Using multiple clinically relevant murine
models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T
cells from specific pathogen-free and germ-free donors, and found that donor microbiota …
The link between microbial flora and the shaping of immune responses is being increasingly appreciated, and recent data have uncovered a role for recipient microbiota in the severity of graft-versus-host disease (GVHD). The impact of donor microbiota on T cell–mediated alloresponses and GVHD is not known, however. Using multiple clinically relevant murine models, we analyzed the effect of donor microbiota on the severity of GVHD induced by T cells from specific pathogen-free and germ-free donors, and found that donor microbiota does not alter the expansion or differentiation of alloreactive T cells or the severity of GVHD.
Elsevier